node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDB0168077 | gefF | Q556V8 | Q54C94 | Uncharacterized protein. | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. | 0.703 |
DDB0189538 | gefF | Q55G82 | Q54C94 | Uncharacterized protein. | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. | 0.452 |
gefF | DDB0168077 | Q54C94 | Q556V8 | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. | Uncharacterized protein. | 0.703 |
gefF | DDB0189538 | Q54C94 | Q55G82 | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. | Uncharacterized protein. | 0.452 |
gefF | gflB | Q54C94 | Q54L90 | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. | Ras guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. | 0.408 |
gefF | rasD | Q54C94 | P03967 | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.488 |
gefF | scaA | Q54C94 | Q54XY4 | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. | 0.441 |
gflB | gefF | Q54L90 | Q54C94 | Ras guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. | 0.408 |
gflB | rasD | Q54L90 | P03967 | Ras guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.536 |
rasD | gefF | P03967 | Q54C94 | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. | 0.488 |
rasD | gflB | P03967 | Q54L90 | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Ras guanine nucleotide exchange factor glfB; GpaB-activated, rapA-specific guanine nucleotide exchange factor, involved in the regulation of the balance between Ras and Rap signaling at the leading edge of chemotaxing cells. Spatially localized activation of Rap and Ras induces F-actin polymerization at the leading edge of chemotaxing cells through the Rac, PI3K, and TORC2 pathways. Acts also as a key regulator of actin-driven membrane protrusions during processes such as phagocytosis and cytokinesis, possibly by modulating rapA signaling pathways. | 0.536 |
rasD | scaA | P03967 | Q54XY4 | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. | 0.537 |
scaA | gefF | Q54XY4 | Q54C94 | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. | Ras guanine nucleotide exchange factor F; Promotes the exchange of Ras-bound GDP by GTP. | 0.441 |
scaA | rasD | Q54XY4 | P03967 | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.537 |