STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0184541Uncharacterized protein. (355 aa)    
Predicted Functional Partners:
captC
Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 3.
   
 
 0.984
captB
Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 2.
   
 
 0.983
captA
Uncharacterized CDP-alcohol phosphatidyltransferase class-I family protein 1.
     
 0.983
PSD2
Phosphatidylserine decarboxylase 2 alpha chain; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.
  
 
0.974
pssA
Phosphatidylserine synthase.
   
 
 0.961
pldA
Phospholipase D A; Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization.
   
 0.943
pldB
Phospholipase D B; Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho (phosphatidylcholine), producing the free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization. Plays an important role in cell migration by localizing along the anterior cell membrane. Overexpression leads to the inability to aggregate even at higher cell density. Also known as a negative regulator of quorum sensing.
   
 0.943
pldC
Phospholipase D C; Plays a role in cell growth. Hydrolyzes membrane phospholipids, such as PtdCho (phosphatidylcholine), producing the free headgroup and PtdOH (phosphatidic acid; signaling molecule on its own). Involved in the inhibition of actin-based motility and endocytosis. Its inhibition causes complete collapse of F-actin organization.
   
 0.943
DDB0205522
Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.
   
 0.937
DDB0168929
Uncharacterized protein.
     
 0.935
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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