node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDB0230179 | adhfe1 | Q558S7 | Q54GJ7 | Isocitrate lyase. | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. | 0.682 |
DDB0230179 | agxt | Q558S7 | Q54GT6 | Isocitrate lyase. | Serine--pyruvate aminotransferase; Dual metabolic roles of gluconeogenesis and glyoxylate detoxification; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | 0.992 |
DDB0230179 | hacl1 | Q558S7 | Q54DA9 | Isocitrate lyase. | Probable 2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2- hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde; Belongs to the TPP enzyme family. | 0.856 |
DDB0230179 | haox | Q558S7 | Q54E41 | Isocitrate lyase. | Hydroxyacid oxidase; Has 2-hydroxyacid oxidase activity; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.991 |
DDB0230179 | hmgL | Q558S7 | Q54QI7 | Isocitrate lyase. | Hydroxymethylglutaryl-CoA lyase. | 0.790 |
DDB0230179 | masB | Q558S7 | Q54RR4 | Isocitrate lyase. | Malate synthase. | 0.999 |
DDB0230179 | pex5 | Q558S7 | Q54MD1 | Isocitrate lyase. | Peroxisomal targeting signal 1 receptor; Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. | 0.749 |
DDB_G0269880 | hacl1 | Q55CV9 | Q54DA9 | CaiB/baiF CoA-transferase family protein DDB_G0269880; Belongs to the CoA-transferase III family. | Probable 2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2- hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde; Belongs to the TPP enzyme family. | 0.802 |
DDB_G0269880 | hmgL | Q55CV9 | Q54QI7 | CaiB/baiF CoA-transferase family protein DDB_G0269880; Belongs to the CoA-transferase III family. | Hydroxymethylglutaryl-CoA lyase. | 0.425 |
adhfe1 | DDB0230179 | Q54GJ7 | Q558S7 | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. | Isocitrate lyase. | 0.682 |
adhfe1 | agxt | Q54GJ7 | Q54GT6 | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. | Serine--pyruvate aminotransferase; Dual metabolic roles of gluconeogenesis and glyoxylate detoxification; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | 0.795 |
adhfe1 | bkdA | Q54GJ7 | Q54M22 | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity); Belongs to the BCKDHA family. | 0.505 |
adhfe1 | hacl1 | Q54GJ7 | Q54DA9 | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. | Probable 2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2- hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde; Belongs to the TPP enzyme family. | 0.777 |
adhfe1 | haox | Q54GJ7 | Q54E41 | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. | Hydroxyacid oxidase; Has 2-hydroxyacid oxidase activity; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. | 0.513 |
adhfe1 | hmgL | Q54GJ7 | Q54QI7 | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. | Hydroxymethylglutaryl-CoA lyase. | 0.854 |
adhfe1 | masB | Q54GJ7 | Q54RR4 | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. | Malate synthase. | 0.682 |
agxt | DDB0230179 | Q54GT6 | Q558S7 | Serine--pyruvate aminotransferase; Dual metabolic roles of gluconeogenesis and glyoxylate detoxification; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | Isocitrate lyase. | 0.992 |
agxt | adhfe1 | Q54GT6 | Q54GJ7 | Serine--pyruvate aminotransferase; Dual metabolic roles of gluconeogenesis and glyoxylate detoxification; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. | 0.795 |
agxt | bcaA | Q54GT6 | Q54N47 | Serine--pyruvate aminotransferase; Dual metabolic roles of gluconeogenesis and glyoxylate detoxification; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | Branched-chain-amino-acid aminotransferase; Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.480 |
agxt | hacl1 | Q54GT6 | Q54DA9 | Serine--pyruvate aminotransferase; Dual metabolic roles of gluconeogenesis and glyoxylate detoxification; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. | Probable 2-hydroxyacyl-CoA lyase 1; Catalyzes a carbon-carbon cleavage reaction; cleaves a 2- hydroxy-3-methylacyl-CoA into formyl-CoA and a 2-methyl-branched fatty aldehyde; Belongs to the TPP enzyme family. | 0.865 |