STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0184257BTB domain-containing protein. (352 aa)    
Predicted Functional Partners:
culC
Cullin-3; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity); Belongs to the cullin family.
    
  0.554
DDB0217858
BTB domain-containing protein.
  
  
0.522
ube2m
NEDD8-conjugating enzyme Ubc12; Accepts the ubiquitin-like protein nedd8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins.
    
  0.516
commd10
COMM domain-containing protein 10.
   
 
  0.511
DDB_G0285813
Coiled-coil domain-containing protein 22 homolog; Belongs to the CCDC22 family.
     
 0.508
nedd8
NEDD8; Ubiquitin-like protein which plays an important role in cell cycle control, embryogenesis and neurogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex ube1c/uba3- ula1 and linkage to the E2 enzyme ube2m/ubc12. Attachment of nedd8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins (By similarity).
    
  0.505
commd4
COMM domain-containing protein 4.
   
 
  0.504
DDB0168798
BTB domain-containing protein.
  
  
 0.504
DDB_G0284369
Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.
   
 
  0.503
commd8
COMM domain-containing protein 8.
   
 
  0.503
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.