STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Vps33Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (644 aa)    
Predicted Functional Partners:
vps16
Vacuolar protein sorting-associated protein 16 homolog; May play a role in vesicle-mediated protein trafficking to endosomal/lysosomal compartments and in membrane docking/fusion reactions; Belongs to the VPS16 family.
   
 0.992
Vps18
Pep3_Vps18 domain-containing protein.
   
 0.992
vps11
Vacuolar protein sorting-associated protein 11 homolog; May play a role in vesicle-mediated protein trafficking. Belongs to the VPS11 family.
   
 0.991
vps39
Tetratricopeptide-like helical domain-containing protein.
   
 0.979
Vps41
RING-type domain-containing protein; Belongs to the VPS41 family.
    
 0.958
vacA2
RING-type domain-containing protein.
    
 0.955
vps45
Vacuolar protein sorting-associated protein 45; May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network; Belongs to the STXBP/unc-18/SEC1 family.
    
 
 0.856
DDB_G0288589
Vacuolar fusion protein CCZ1 homolog; Belongs to the CCZ1 family.
    
 
 0.843
vti1A
Vesicle transport through interaction with t-SNAREs homolog 1A; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Belongs to the VTI1 family.
   
 
 0.784
sec1
Protein transport protein sec1; Involved in the vesicle trafficking. Binds syntaxins (By similarity); Belongs to the STXBP/unc-18/SEC1 family.
   
  
 0.742
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.