STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
shkEDual specificity protein kinase shkE; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily. (710 aa)    
Predicted Functional Partners:
ndrC
Probable serine/threonine-protein kinase ndrC; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  
   0.551
DDB_G0290859
Probable serine/threonine-protein kinase DDB_G0290859; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  
 
   0.496
ndrB
Probable serine/threonine-protein kinase ndrB.
  
 
   0.457
mekA
Dual specificity mitogen-activated protein kinase kinase 1; Required for cAMP-mediated activation of guanylyl cyclase activity and plays an essential role in aggregation, morphogenesis, and chemotaxis. Appears to act upstream of erk1 but not erk2.
  
 
0.450
ndrA
Probable serine/threonine-protein kinase ndrA.
  
 
   0.431
DDB_G0268656
Probable inactive serine/threonine-protein kinase DDB_G0268656.
  
 
   0.410
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.