node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Pde4 | pde3 | Q86H13 | B0G0Y8 | cAMP-specific 3',5'-cAMP phosphodiesterase 4; Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development; Belongs to the cyclic nucleotide phosphodiesterase family. | cGMP-specific 3',5'-cGMP phosphodiesterase 3; Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP. | 0.887 |
Pde4 | pde7 | Q86H13 | Q54HY0 | cAMP-specific 3',5'-cAMP phosphodiesterase 4; Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development; Belongs to the cyclic nucleotide phosphodiesterase family. | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 7; Phosphodiesterase with dual cAMP/cGMP specificity. However, displays a preference for cAMP over cGMP. Seems to regulate cAMP/cGMP concentration especially during cell aggregation. | 0.821 |
Pde4 | pdeD | Q86H13 | Q8MLZ3 | cAMP-specific 3',5'-cAMP phosphodiesterase 4; Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development; Belongs to the cyclic nucleotide phosphodiesterase family. | cGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. | 0.556 |
Pde4 | pdeE | Q86H13 | Q8MM62 | cAMP-specific 3',5'-cAMP phosphodiesterase 4; Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development; Belongs to the cyclic nucleotide phosphodiesterase family. | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B; Dual specificity cAMP and cGMP phosphodiesterase with marked preference for cyclic AMP, which is activated by cAMP and cGMP. Likely functions as a cAMP-stimulated cAMP-phosphodiesterase which may play a role in regulating the cAMP relay response. Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family. | 0.634 |
Pde4 | regA | Q86H13 | Q23917 | cAMP-specific 3',5'-cAMP phosphodiesterase 4; Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development; Belongs to the cyclic nucleotide phosphodiesterase family. | 3',5'-cyclic-nucleotide phosphodiesterase regA; Phosphodiesterase specific for cAMP. Involved in the degradation of intracellular cAMP. Morphological suppressor of tagB. Phosphorelay protein that accepts phosphate from rdeA or supplies phosphate from regA; depending on the relative concentration of the phosphodonor proteins; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.938 |
pde3 | Pde4 | B0G0Y8 | Q86H13 | cGMP-specific 3',5'-cGMP phosphodiesterase 3; Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP. | cAMP-specific 3',5'-cAMP phosphodiesterase 4; Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.887 |
pde3 | pde7 | B0G0Y8 | Q54HY0 | cGMP-specific 3',5'-cGMP phosphodiesterase 3; Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP. | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 7; Phosphodiesterase with dual cAMP/cGMP specificity. However, displays a preference for cAMP over cGMP. Seems to regulate cAMP/cGMP concentration especially during cell aggregation. | 0.761 |
pde3 | pdeD | B0G0Y8 | Q8MLZ3 | cGMP-specific 3',5'-cGMP phosphodiesterase 3; Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP. | cGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. | 0.823 |
pde3 | pdeE | B0G0Y8 | Q8MM62 | cGMP-specific 3',5'-cGMP phosphodiesterase 3; Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP. | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B; Dual specificity cAMP and cGMP phosphodiesterase with marked preference for cyclic AMP, which is activated by cAMP and cGMP. Likely functions as a cAMP-stimulated cAMP-phosphodiesterase which may play a role in regulating the cAMP relay response. Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family. | 0.762 |
pde7 | Pde4 | Q54HY0 | Q86H13 | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 7; Phosphodiesterase with dual cAMP/cGMP specificity. However, displays a preference for cAMP over cGMP. Seems to regulate cAMP/cGMP concentration especially during cell aggregation. | cAMP-specific 3',5'-cAMP phosphodiesterase 4; Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.821 |
pde7 | pde3 | Q54HY0 | B0G0Y8 | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 7; Phosphodiesterase with dual cAMP/cGMP specificity. However, displays a preference for cAMP over cGMP. Seems to regulate cAMP/cGMP concentration especially during cell aggregation. | cGMP-specific 3',5'-cGMP phosphodiesterase 3; Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP. | 0.761 |
pde7 | pdeD | Q54HY0 | Q8MLZ3 | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 7; Phosphodiesterase with dual cAMP/cGMP specificity. However, displays a preference for cAMP over cGMP. Seems to regulate cAMP/cGMP concentration especially during cell aggregation. | cGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. | 0.492 |
pde7 | pdeE | Q54HY0 | Q8MM62 | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 7; Phosphodiesterase with dual cAMP/cGMP specificity. However, displays a preference for cAMP over cGMP. Seems to regulate cAMP/cGMP concentration especially during cell aggregation. | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B; Dual specificity cAMP and cGMP phosphodiesterase with marked preference for cyclic AMP, which is activated by cAMP and cGMP. Likely functions as a cAMP-stimulated cAMP-phosphodiesterase which may play a role in regulating the cAMP relay response. Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family. | 0.728 |
pde7 | regA | Q54HY0 | Q23917 | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 7; Phosphodiesterase with dual cAMP/cGMP specificity. However, displays a preference for cAMP over cGMP. Seems to regulate cAMP/cGMP concentration especially during cell aggregation. | 3',5'-cyclic-nucleotide phosphodiesterase regA; Phosphodiesterase specific for cAMP. Involved in the degradation of intracellular cAMP. Morphological suppressor of tagB. Phosphorelay protein that accepts phosphate from rdeA or supplies phosphate from regA; depending on the relative concentration of the phosphodonor proteins; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.548 |
pdeD | Pde4 | Q8MLZ3 | Q86H13 | cGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. | cAMP-specific 3',5'-cAMP phosphodiesterase 4; Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.556 |
pdeD | pde3 | Q8MLZ3 | B0G0Y8 | cGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. | cGMP-specific 3',5'-cGMP phosphodiesterase 3; Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP. | 0.823 |
pdeD | pde7 | Q8MLZ3 | Q54HY0 | cGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 7; Phosphodiesterase with dual cAMP/cGMP specificity. However, displays a preference for cAMP over cGMP. Seems to regulate cAMP/cGMP concentration especially during cell aggregation. | 0.492 |
pdeD | pdeE | Q8MLZ3 | Q8MM62 | cGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B; Dual specificity cAMP and cGMP phosphodiesterase with marked preference for cyclic AMP, which is activated by cAMP and cGMP. Likely functions as a cAMP-stimulated cAMP-phosphodiesterase which may play a role in regulating the cAMP relay response. Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family. | 0.430 |
pdeD | regA | Q8MLZ3 | Q23917 | cGMP-dependent 3',5'-cGMP phosphodiesterase A; Phosphodiesterase specific for cGMP, which is activated by cGMP but not by cAMP. Involved in the degradation of intracellular cGMP. | 3',5'-cyclic-nucleotide phosphodiesterase regA; Phosphodiesterase specific for cAMP. Involved in the degradation of intracellular cAMP. Morphological suppressor of tagB. Phosphorelay protein that accepts phosphate from rdeA or supplies phosphate from regA; depending on the relative concentration of the phosphodonor proteins; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.553 |
pdeE | Pde4 | Q8MM62 | Q86H13 | cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B; Dual specificity cAMP and cGMP phosphodiesterase with marked preference for cyclic AMP, which is activated by cAMP and cGMP. Likely functions as a cAMP-stimulated cAMP-phosphodiesterase which may play a role in regulating the cAMP relay response. Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family. | cAMP-specific 3',5'-cAMP phosphodiesterase 4; Phosphodiesterase specific for extracellular cAMP. Involved in the degradation of extracellular cAMP specifically during multicellular development; Belongs to the cyclic nucleotide phosphodiesterase family. | 0.634 |