STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
rgaARas GTPase-activating-like protein rgaA; Part of signaling pathway that is required for completion of cytokinesis. gapA and rgaA control cortexillin localization to the cleavage furrow and hence may be involved in cleavage of the midbody in the final stage of cytokinesis by regulating the actin cytoskeleton. Forms a complex by linking activated rac1A to ctxA. Assembly of this complex is necessary for the recruitment of cortexillin to the midzone of a dividing cell. Overexpression leads to the suppression of the formation of cellular projections containing F-actin and to a defect in cyt [...] (822 aa)    
Predicted Functional Partners:
rac1A
Rho-related protein rac1A; Overexpression promotes the formation of filopodia and membrane ruffles; Belongs to the small GTPase superfamily. Rho family.
   
 0.909
ctxA
Cortexillin-1; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1; Belongs to the cortexillin family.
   
 
 0.854
rasD
Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.
    
 0.851
mhcA
Myosin-2 heavy chain; Myosin is a protein that binds to actin and has ATPase activity that is activated by actin; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
   
 
 0.808
rasG
Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.
    
 0.747
ctxB
Cortexillin-2; Actin-bundling protein. When linked to F-actin the actin filaments form preferentially anti-parallel bundles that associate into meshworks. Plays a major role in cytokinesis. Negatively regulates cortical localization of rapgap1 (By similarity); Belongs to the cortexillin family.
   
 
 0.741
racD
Rho-related protein racD; Belongs to the small GTPase superfamily. Rho family.
   
 0.602
pakB
Serine/threonine-protein kinase pakB; Regulator of the myosin I component of the cytoskeleton: required for regulation of cytokinesis, phagocytosis and pinocytosis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    
 0.600
rasB
Ras-like protein rasB; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.
    
 0.595
rasC
Ras-like protein rasC; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family.
    
 0.595
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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