STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ubiad1UbiA prenyltransferase domain-containing protein 1; Prenyltransferase that mediates the formation of menaquinone- 4 (MK-4), a vitamin K2 isoform. (330 aa)    
Predicted Functional Partners:
coq2
4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB.
    
 0.753
med23
Putative mediator of RNA polymerase II transcription subunit 23; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
      
 0.701
ipi
Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
    
 0.661
haox
Hydroxyacid oxidase; Has 2-hydroxyacid oxidase activity; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
     
 0.654
usp12
Ubiquitin carboxyl-terminal hydrolase.
      
 0.643
ddx17
Probable ATP-dependent RNA helicase ddx17; Probable ATP-dependent RNA helicase which may be involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing; Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
  
  
 0.594
hmgA
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1; This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis; Belongs to the HMG-CoA reductase family.
   
 
 0.549
hmgB
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2; This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of the sterol biosynthesis.
   
 
 0.549
DDB0183890
Uncharacterized protein.
     
 0.484
DDB0216922
Uncharacterized protein.
     
 0.484
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.