STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ncbp2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp2 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap struct [...] (234 aa)    
Predicted Functional Partners:
ncbp1
Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing and RNA-mediated gene silencing (RNAi). The CBC complex is involved in miRNA-mediated RNA interference and is required for primary microRNAs (miRNAs) processing. In the CBC complex, ncbp1 does not bind directly capped RNAs (m7GpppG- capped RNA) but is required to stabilize the movement of the N-terminal loop of ncbp2 and lock the CBC into a high affinity cap-binding state with the cap [...]
   
 0.999
DDB0217966
Uncharacterized protein.
    
 0.987
snrpE
Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family.
   
 0.974
Rbm8A
RRM domain-containing protein.
   
 0.971
snrpG
Probable small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
   
 0.967
snrpD3
Small nuclear ribonucleoprotein Sm D3.
   
 0.960
snrpf
Small nuclear ribonucleoprotein F; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome.
   
  0.955
snrpd2
Probable small nuclear ribonucleoprotein Sm D2; Core component of the small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs (By similarity).
   
 
 0.949
Sf3a3
Zn finger-containing protein.
   
 
 0.944
DDB_G0291015
Putative uncharacterized protein DDB_G0291015.
   
 0.930
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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