node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDB0186943 | DDB_G0284369 | Q54LV9 | B0G147 | Uncharacterized protein. | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | 0.502 |
DDB0186943 | DDB_G0290025 | Q54LV9 | Q54GP1 | Uncharacterized protein. | DCN1-like protein 1; May contribute to neddylation of cullin components of SCF- type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity). | 0.502 |
DDB0186943 | csn2 | Q54LV9 | Q54HL6 | Uncharacterized protein. | COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. | 0.555 |
DDB0186943 | csn3 | Q54LV9 | Q54E53 | Uncharacterized protein. | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. | 0.557 |
DDB0186943 | csn5 | Q54LV9 | Q54PF3 | Uncharacterized protein. | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligasew complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. Csn5 is essential for growth or survival. | 0.562 |
DDB0186943 | csn6 | Q54LV9 | Q54C92 | Uncharacterized protein. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity; Belongs to the peptidase M67A family. CSN6 subfamily. | 0.559 |
DDB0186943 | csn8 | Q54LV9 | Q75K24 | Uncharacterized protein. | COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. | 0.528 |
DDB0186943 | culC | Q54LV9 | Q54NZ5 | Uncharacterized protein. | Cullin-3; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity); Belongs to the cullin family. | 0.582 |
DDB0186943 | uba3 | Q54LV9 | Q54QG9 | Uncharacterized protein. | NEDD8-activating enzyme E1 catalytic subunit; Regulatory subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). | 0.508 |
DDB0186943 | ube2m | Q54LV9 | Q54TI6 | Uncharacterized protein. | NEDD8-conjugating enzyme Ubc12; Accepts the ubiquitin-like protein nedd8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. | 0.574 |
DDB_G0284369 | DDB0186943 | B0G147 | Q54LV9 | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | Uncharacterized protein. | 0.502 |
DDB_G0284369 | DDB_G0290025 | B0G147 | Q54GP1 | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | DCN1-like protein 1; May contribute to neddylation of cullin components of SCF- type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity). | 0.478 |
DDB_G0284369 | csn2 | B0G147 | Q54HL6 | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | COP9 signalosome complex subunit 2; Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. | 0.427 |
DDB_G0284369 | csn3 | B0G147 | Q54E53 | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. | 0.426 |
DDB_G0284369 | csn5 | B0G147 | Q54PF3 | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligasew complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. Csn5 is essential for growth or survival. | 0.596 |
DDB_G0284369 | csn6 | B0G147 | Q54C92 | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity; Belongs to the peptidase M67A family. CSN6 subfamily. | 0.464 |
DDB_G0284369 | csn8 | B0G147 | Q75K24 | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | COP9 signalosome complex subunit 8; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity. | 0.430 |
DDB_G0284369 | culC | B0G147 | Q54NZ5 | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | Cullin-3; Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity); Belongs to the cullin family. | 0.734 |
DDB_G0284369 | uba3 | B0G147 | Q54QG9 | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | NEDD8-activating enzyme E1 catalytic subunit; Regulatory subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). | 0.645 |
DDB_G0284369 | ube2m | B0G147 | Q54TI6 | Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | NEDD8-conjugating enzyme Ubc12; Accepts the ubiquitin-like protein nedd8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. | 0.843 |