STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdc25M-phase inducer phosphatase; Tyrosine protein phosphatase which may function as a dosage- dependent inducer in mitotic control; Belongs to the MPI phosphatase family. (1053 aa)    
Predicted Functional Partners:
fttB
14-3-3-like protein; Belongs to the 14-3-3 family.
    
 0.927
cdk1
Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
   
 0.907
cycB
G2/mitotic-specific cyclin-B; Essential for the control of the cell cycle at the G2/M (mitosis) transition.
   
 0.905
PLK
Probable serine/threonine-protein kinase PLK; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
   
 0.876
fhkE
Probable serine/threonine-protein kinase fhkE; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily.
   
 0.851
DDB_G0277165
Probable serine/threonine-protein kinase DDB_G0277165; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
    
 
 0.796
DDB0217499
Ubiquitin carboxyl-terminal hydrolase.
   
 0.708
DDB0216068
Uncharacterized protein.
   
  
 0.644
orcE
Origin recognition complex subunit 5; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
   
   0.614
orcC
Origin recognition complex subunit 3; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication (By similarity).
    
   0.612
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.