STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0218520Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (551 aa)    
Predicted Functional Partners:
atg8
Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. Participates in membrane fusion events that take place in the secretory pathway (By similarity); Belongs to the ATG8 family.
  
 0.994
DDB_G0290491
Autophagy-related protein 8-like protein DDB_G0290491.
  
 0.989
atg3
Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), and autophagy. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of atg8. The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8 from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8. The formation of the atg8- phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt) (By similarity).
   
 
 0.917
atg4-1
Cysteine protease atg4; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of atg8 to reveal a C-terminal glycine. Exposure of the glycine at the C- terminus is essential for atg8 conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity); Belongs to the peptidase C54 family.
  
  
 
0.914
atg7
Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the atg8 association to autophagosomes membranes (By similarity). Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.
   
 
 0.871
DDB_G0291918
Probable serine/threonine-protein kinase DDB_G0291918; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
   
 
 0.856
atg1
Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in autophagy. Involved in the control of autophagic vacuolar cell death. Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.
   
 
 0.856
atg12
Ubiquitin-like protein atg12; Ubiquitin-like protein involved in autophagy vesicles formation. Required for atg8 association to the vesicle membranes. Conjugated to atg5 through a ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme is essential for its function (By similarity); Belongs to the ATG12 family.
   
 
 0.737
DDB0185872
PB1 domain-containing protein.
    
 
 0.711
DDB0190801
Uncharacterized protein.
    
 
 0.711
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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