STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0185649Uncharacterized protein. (729 aa)    
Predicted Functional Partners:
gabT
4-aminobutyrate aminotransferase.
  
 0.538
DDB_G0290721
Aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.515
sdhA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
 
 
 0.460
sppA
Probable sphingosine-1-phosphate phosphatase; Has enzymatic activity against both sphingosine 1 phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels (By similarity); Belongs to the type 2 lipid phosphate phosphatase family.
    
 0.459
DDB0231503
Aldehyde dehydrogenase.
   
 0.454
DDB0187592
Uncharacterized protein.
   
 
 0.446
sgkB
Sphingosine kinase B; Catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), which probably acts intracellularly as a second messenger perhaps by promoting cell proliferation.
  
 0.432
gluD
Glutamate dehydrogenase, mitochondrial.
   
 
 0.421
glud2
Glutamate dehydrogenase 2; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
   
 
 0.421
SgkD
DAGKc domain-containing protein.
  
 0.417
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.