STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nrde2Nuclear exosome regulator NRDE2; Protein of the nuclear speckles that regulates RNA exosomal degradation; Belongs to the NRDE2 family. (1320 aa)    
Predicted Functional Partners:
rsmL
Rab GTPase.
    
 
 0.908
DDB0167152
Uncharacterized protein.
    
 
 0.907
DDB0219848
Uncharacterized protein.
    
 
 0.831
phr2aB
Serine/threonine-protein phosphatase 2A regulatory subunit phr2AB; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
    
 
 0.831
DDB_G0282777
Probable serine/threonine-protein kinase DDB_G0282777; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    
 
 0.733
PLK
Probable serine/threonine-protein kinase PLK; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
    
 
 0.733
wdr5
WD repeat-containing protein 5 homolog; Belongs to the WD repeat WDR5/wds family.
      
 0.702
DDB0186876
Uncharacterized protein.
    
 
 0.642
stip-1
Septin and tuftelin-interacting protein 1 homolog; May be involved in pre-mRNA splicing.
   
   0.596
mad2l1-1
Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex until all chromosomes are aligned at the metaphase plate (By similarity). Belongs to the MAD2 family.
    
 
 0.576
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.