STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB_G0282777Probable serine/threonine-protein kinase DDB_G0282777; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (639 aa)    
Predicted Functional Partners:
DDB0188839
Peptidase C50 domain-containing protein.
   
 
 0.918
DDB0186876
Uncharacterized protein.
   
 
 0.900
rsmL
Rab GTPase.
    
 
 0.879
DDB0190924
DBF4-type domain-containing protein.
   
 
 0.850
smc1
Structural maintenance of chromosomes protein.
   
 
 0.847
DDB0202625
Uncharacterized protein.
   
 
 0.843
DDB0219848
Uncharacterized protein.
    
 
 0.797
phr2aB
Serine/threonine-protein phosphatase 2A regulatory subunit phr2AB; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
    
 
 0.797
bub1
Probable inactive serine/threonine-protein kinase bub1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. BUB1 subfamily.
   
 
 0.790
pho2a
Serine/threonine-protein phosphatase 2A catalytic subunit A; Plays a role in activating the myosin contractile function. Dephosphorylates threonine at 'Thr-1823', 'Thr-1833' and 'Thr-2029' in the C-terminal tail region of myosin II heavy chain (mhcA). Drives the assembly of dephosphorylated myosin II filaments to allow myosin recruitment into the cytoskeleton.
    
 
 0.789
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.