STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0204786RING-type domain-containing protein. (320 aa)    
Predicted Functional Partners:
DDB0217880
UBA_e1_C domain-containing protein.
   
 
 0.513
atg7
Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for autophagy. Activates atg12 for its conjugation with atg5 and atg8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the atg8 association to autophagosomes membranes (By similarity). Required for normal survival when exposed to pathogenic bacteria S.typhimurium by promoting autophagic degradation of intracellular S.typhimurium.
   
 
 0.512
uba3
NEDD8-activating enzyme E1 catalytic subunit; Regulatory subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity).
   
 
  0.505
uba5
Ubiquitin-like modifier-activating enzyme 5; E1-like enzyme which activates ufm1.
   
 
  0.502
DDB0187273
Metallophos_2 domain-containing protein.
   
   0.488
ubxd7
UBX domain-containing protein 7 homolog.
   
   0.438
pex4
Ubiquitin-conjugating enzyme E2 pex4; Catalyzes the covalent attachment of ubiquitin to other proteins. Essential for peroxisome biogenesis.
  
 
 0.429
DDB0204602
RING-type domain-containing protein.
     
 
0.400
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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