node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDB0185872 | DDB0190801 | Q54Q21 | Q55CE3 | PB1 domain-containing protein. | Uncharacterized protein. | 0.969 |
DDB0185872 | DDB0204758 | Q54Q21 | Q54SI9 | PB1 domain-containing protein. | Ubiquitin-like domain-containing protein. | 0.776 |
DDB0190801 | DDB0185872 | Q55CE3 | Q54Q21 | Uncharacterized protein. | PB1 domain-containing protein. | 0.969 |
DDB0190801 | DDB0204758 | Q55CE3 | Q54SI9 | Uncharacterized protein. | Ubiquitin-like domain-containing protein. | 0.776 |
DDB0203824 | DDB0204758 | Q551R4 | Q54SI9 | VWFA domain-containing protein. | Ubiquitin-like domain-containing protein. | 0.591 |
DDB0204758 | DDB0185872 | Q54SI9 | Q54Q21 | Ubiquitin-like domain-containing protein. | PB1 domain-containing protein. | 0.776 |
DDB0204758 | DDB0190801 | Q54SI9 | Q55CE3 | Ubiquitin-like domain-containing protein. | Uncharacterized protein. | 0.776 |
DDB0204758 | DDB0203824 | Q54SI9 | Q551R4 | Ubiquitin-like domain-containing protein. | VWFA domain-containing protein. | 0.591 |
DDB0204758 | csn5 | Q54SI9 | Q54PF3 | Ubiquitin-like domain-containing protein. | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligasew complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. Csn5 is essential for growth or survival. | 0.615 |
DDB0204758 | csn6 | Q54SI9 | Q54C92 | Ubiquitin-like domain-containing protein. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity; Belongs to the peptidase M67A family. CSN6 subfamily. | 0.611 |
DDB0204758 | nae1 | Q54SI9 | Q54JM3 | Ubiquitin-like domain-containing protein. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity); Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.608 |
DDB0204758 | rps25 | Q54SI9 | Q03409 | Ubiquitin-like domain-containing protein. | 40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. | 0.577 |
DDB0204758 | senp8 | Q54SI9 | Q54XR2 | Ubiquitin-like domain-containing protein. | Probable sentrin-specific protease 8; Protease that catalyzes two essential functions in the nedd8 pathway: processing of full-length nedd8 to its mature form and deconjugation of nedd8 from targeted proteins. | 0.608 |
DDB0204758 | uba3 | Q54SI9 | Q54QG9 | Ubiquitin-like domain-containing protein. | NEDD8-activating enzyme E1 catalytic subunit; Regulatory subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity). | 0.593 |
DDB0204758 | ube2m | Q54SI9 | Q54TI6 | Ubiquitin-like domain-containing protein. | NEDD8-conjugating enzyme Ubc12; Accepts the ubiquitin-like protein nedd8 from the uba3-nae1 E1 complex and catalyzes its covalent attachment to other proteins. | 0.579 |
csn5 | DDB0204758 | Q54PF3 | Q54SI9 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligasew complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. Csn5 is essential for growth or survival. | Ubiquitin-like domain-containing protein. | 0.615 |
csn5 | csn6 | Q54PF3 | Q54C92 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligasew complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. Csn5 is essential for growth or survival. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity; Belongs to the peptidase M67A family. CSN6 subfamily. | 0.999 |
csn5 | nae1 | Q54PF3 | Q54JM3 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligasew complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. Csn5 is essential for growth or survival. | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric uba3-nae1 E1 enzyme. E1 activates nedd8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a nedd8-uba3 thioester and free AMP. E1 finally transfers nedd8 to the catalytic cysteine of ube2m (By similarity); Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. | 0.702 |
csn5 | rps25 | Q54PF3 | Q03409 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligasew complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. Csn5 is essential for growth or survival. | 40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family. | 0.407 |
csn5 | senp8 | Q54PF3 | Q54XR2 | COP9 signalosome complex subunit 5; Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligasew complexes, leading to modify the Ubl ligase activity. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. Csn5 is essential for growth or survival. | Probable sentrin-specific protease 8; Protease that catalyzes two essential functions in the nedd8 pathway: processing of full-length nedd8 to its mature form and deconjugation of nedd8 from targeted proteins. | 0.466 |