STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pola1DNA polymerase alpha catalytic subunit; Polymerase alpha in a complex with DNA primase is a replicative polymerase; Belongs to the DNA polymerase type-B family. (1509 aa)    
Predicted Functional Partners:
DDB0186711
DNA primase; Belongs to the eukaryotic-type primase small subunit family.
   
 0.999
polA2
DNA polymerase alpha subunit B; May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.
   
 0.999
prim2
DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.
   
 0.999
DDB0189629
Uncharacterized protein.
   
 
 0.997
PolD2
Uncharacterized protein.
   
 0.992
pole
DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication.
   
 0.979
pole2
DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity).
   
 0.979
cdc45
Cell division control protein 45 homolog; Required for initiation of chromosomal DNA replication. Belongs to the CDC45 family.
   
 
 0.973
pcna
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.
  
 0.953
Mcm4
DNA helicase; Belongs to the MCM family.
   
 
 0.943
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.