STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB_G0281599Coiled-coil domain-containing protein 130 homolog; Belongs to the CWC16 family. (325 aa)    
Predicted Functional Partners:
prp19
Pre-mRNA-processing factor 19; Probable ubiquitin-protein ligase mainly involved in pre-mRNA splicing and DNA repair. Core component of the Prp19 complex/PRP19C/Nineteen complex/NTC which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity.
    
   0.938
Cdc40
WD_REPEATS_REGION domain-containing protein.
    
   0.923
Eftud2
Tr-type G domain-containing protein.
    
   0.923
cdc5l
Cell division cycle 5-like protein; DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. May also play a role in the response to DNA damage (DDR).
    
   0.923
Syf2
Uncharacterized protein.
    
 0.645
xab2
Pre-mRNA-splicing factor SYF1; Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.
   
 0.588
DDB0167930
Uncharacterized protein.
   
  0.577
rtf2
Replication termination factor 2; Replication termination factor which is a component of the elongating replisome. Interacts with nascent DNA. Belongs to the rtf2 family.
   
  
 0.576
DDB0218683
Uncharacterized protein.
    
  0.558
stip-1
Septin and tuftelin-interacting protein 1 homolog; May be involved in pre-mRNA splicing.
    
  0.551
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.