STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
shkDDual specificity protein kinase shkD; Required for proper chemotaxis and phagocytosis; proper spatiotemporal control of F-actin levels in chemotaxing cells. Negative regulator of the PI3K (phosphatidylinositol 3 kinase) pathway. Predominantly phosphorylates serines and threonines and tyrosines at a lower level (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. SH2 domain-containing protein kinase subfamily. (744 aa)    
Predicted Functional Partners:
lkb1
Serine/threonine-protein kinase stk11 homolog; Serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.
  
 
 0.532
DDB0188271
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
    
 
 0.515
DDB0167345
Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
 
 0.511
DDB_G0290859
Probable serine/threonine-protein kinase DDB_G0290859; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
  
 
   0.476
DDB0191770
S5 DRBM domain-containing protein.
   
 
 0.473
DDB0218420
Uncharacterized protein.
    
 
 0.463
tmem184F
Transmembrane protein 184F.
    
 
 0.462
DDB0217111
Reverse transcriptase domain-containing protein.
   
  
 0.452
mcfX
Mitochondrial substrate carrier family protein X; Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane.
   
  
 0.450
svkA
Serine/threonine-protein kinase svkA; Involved in regulation of actin cytoskeleton organization during cell motility; F-actin fragmenting and capping protein allowing dynamic rearrangements of the actin cytoskeleton. Also part of a regulatory pathway from the centrosome to the midzone, thus regulating the completion of cell division; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
  
 
 
0.449
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.