STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0218289WD_REPEATS_REGION domain-containing protein. (718 aa)    
Predicted Functional Partners:
DDB_G0277533
WD repeat-containing protein 48 homolog; Belongs to the WD repeat WDR48 family.
   
 0.988
usp12
Ubiquitin carboxyl-terminal hydrolase.
   
 0.975
DDB0202883
USP domain-containing protein; Belongs to the peptidase C19 family.
   
 
 0.883
adcF
Arrestin domain-containing protein F; Belongs to the arrestin family.
   
  
 0.694
mad2l1-1
Mitotic spindle assembly checkpoint protein MAD2A; Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. Required for the execution of the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and inhibits the activity of the anaphase promoting complex until all chromosomes are aligned at the metaphase plate (By similarity). Belongs to the MAD2 family.
   
 
 0.536
TAF9
Transcription initiation factor TFIID subunit.
   
 
 0.513
TAF12
Transcription initiation factor TFIID subunit 12; Part of the multimeric TFIID complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF12 family.
   
 
 0.511
TAF6
TATA-binding protein-associated-factor.
    
 
 0.508
cdk1
Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
   
 
 0.497
cdk5
Cyclin-dependent kinase 5 homolog.
   
 
 0.497
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.