STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hdaDType-2 histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (1489 aa)    
Predicted Functional Partners:
DDB_G0293674
Heat shock cognate 70 kDa protein 3; May function in protein folding and assembly, and disassembly of protein complexes.
    
 
 0.810
DDB0217537
Uncharacterized protein.
    
 
 0.797
DDB0189571
FAD-binding FR-type domain-containing protein.
    
 
 0.795
DDB0187735
Uncharacterized protein.
      
 0.792
DDB0216389
DUF51 family protein.
      
 0.792
DDB0217941
Methyltransf_12 domain-containing protein.
      
 0.792
polr1b
DNA-directed RNA polymerase I subunit rpa2; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
   
 
 0.781
rbbD
Probable histone-binding protein rbbD; Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism (By similarity).
   
 
 0.653
mef2A
Transcription factor mef2A; Transcription factor that regulates cell differentiation during development. Seems to negatively regulate prestalk gene expression and positively regulate prespore gene expression.
   
 
 0.620
set1
Histone-lysine N-methyltransferase set1; Histone methyltransferase that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3. May act to regulate chromatin-mediated events; Belongs to the class V-like SAM-binding methyltransferase superfamily.
  
 
 0.616
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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