STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
racORho-related protein racO. (276 aa)    
Predicted Functional Partners:
gxcB
Rac guanine nucleotide exchange factor B; Involved in the regulation of the late steps of the endocytic pathway.
    
 
 0.876
GxcKK
Uncharacterized protein.
    
 
 0.864
gefS
Ras guanine nucleotide exchange factor S; Promotes the exchange of Ras-bound GDP by GTP.
    
 
 0.822
mgp1
Mental retardation GTPase activating protein homolog 1; Rho GTPase-activating protein involved in the signal transduction pathway (By similarity). Regulator of the contractile vacuole network as well as involved in driving vacuole emptying.
    
 
 0.781
rdiA
Putative rho GDP-dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (By similarity). Regulates the Rac-dependent signaling pathways controlling cytokinesis, actin reorganization and the contractile vacuole. Required for efficient accumulation of cap at the cell cortex.
   
 0.750
rabif
Mss4-like family protein.
    
 
 0.726
cofA
Cofilin-1A; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods (By similarity); Belongs to the actin-binding proteins ADF family.
   
 
 0.721
pirA
Protein pirA; Involved in regulation of actin and microtubule organization.
    
 0.697
brk1
Protein BRICK1; Involved in regulation of actin and microtubule organization. Belongs to the BRK1 family.
   
 0.686
pakC
Serine/threonine-protein kinase pakC; Has role in the regulation of chemotaxis.
   
 0.648
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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