STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ddx20Probable ATP-dependent RNA helicase ddx20; Probable ATP-binding RNA helicase which may be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DDX20 subfamily. (849 aa)    
Predicted Functional Partners:
strap
Serine-threonine kinase receptor-associated protein; The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. STRAP may play a role in the cellular distribution of the SMN complex (By similarity); Belongs to the WD repeat STRAP family.
   
 0.980
gemin2
Gem-associated protein 2; May play an essential role in spliceosomal snRNP assembly in the cytoplasm and may be required for pre-mRNA splicing in the nucleus. Belongs to the gemin-2 family.
   
 0.927
gemin5
Component of gems protein 5; Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Gemin5 acts as the snRNA-binding protein of the SMN complex. Binds to the 7- methylguanosine cap of RNA molecules; Belongs to the WD repeat gemin-5 family.
   
 0.925
gemin1
Component of gems protein 1; May play an essential role in spliceosomal snRNP assembly in the cytoplasm and may be required for pre-mRNA splicing in the nucleus. Belongs to the SMN family.
   
 
 0.887
atp5f1b
ATP synthase subunit beta, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the c [...]
    
 
 0.863
timm50
Mitochondrial import inner membrane translocase subunit tim50; Component of the mitochondrial import inner membrane translocase that mediates the translocation of transit peptide- containing proteins across the mitochondrial inner membrane.
   
  
 0.844
phbB
Prohibitin-2; Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins.
   
 
 0.822
Nup93
Nuclear pore protein.
   
 
 0.787
mef2A
Transcription factor mef2A; Transcription factor that regulates cell differentiation during development. Seems to negatively regulate prestalk gene expression and positively regulate prespore gene expression.
      
 0.700
SnrpD1
Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family.
   
 0.699
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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