STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ifkBProbable serine/threonine-protein kinase ifkB; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. (1358 aa)    
Predicted Functional Partners:
eif2s1
Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...]
   
 0.991
mhisS
Probable histidine--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family.
      
 0.810
bzpR
Probable basic-leucine zipper transcription factor R; Probable transcriptional regulator; Belongs to the bZIP family.
    
 
 0.784
maspS
Aspartate--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.
  
  
 0.605
argC
N-acetyl-gamma-glutamyl-phosphate reductase; In the C-terminal section; belongs to the NAGSA dehydrogenase family.
  
  
 0.527
ifkC
Probable serine/threonine-protein kinase ifkC; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
  
   
0.458
eif2b1
Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family.
   
 
 0.438
gcn1
eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the gcn2 protein kinase activity in response to amino acid starvation. Forms a complex with eif2ak4/gcn2 on translating ribosomes; during this process, gcn1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of eif2ak4/gcn2, and hence stimulating eif2ak4/gcn2 kinase activity. Participates in the repression of global protein synthesis and in gene- specific mRNA translation activation, such as the transcriptional activator atf4, by promoting [...]
   
 
 0.434
malaS
Alanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family.
  
 
 0.425
eif2a
Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.
   
 
 0.416
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: low (28%) [HD]