node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
argC | ifkB | Q54M18 | Q550L8 | N-acetyl-gamma-glutamyl-phosphate reductase; In the C-terminal section; belongs to the NAGSA dehydrogenase family. | Probable serine/threonine-protein kinase ifkB; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.527 |
argC | ifkC | Q54M18 | Q75JN1 | N-acetyl-gamma-glutamyl-phosphate reductase; In the C-terminal section; belongs to the NAGSA dehydrogenase family. | Probable serine/threonine-protein kinase ifkC; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.527 |
argC | malaS | Q54M18 | Q86H43 | N-acetyl-gamma-glutamyl-phosphate reductase; In the C-terminal section; belongs to the NAGSA dehydrogenase family. | Alanine--tRNA ligase, mitochondrial; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.561 |
argC | maspS | Q54M18 | Q55C99 | N-acetyl-gamma-glutamyl-phosphate reductase; In the C-terminal section; belongs to the NAGSA dehydrogenase family. | Aspartate--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | 0.765 |
argC | mhisS | Q54M18 | Q55D12 | N-acetyl-gamma-glutamyl-phosphate reductase; In the C-terminal section; belongs to the NAGSA dehydrogenase family. | Probable histidine--tRNA ligase, mitochondrial; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.527 |
bzpR | eif2s1 | Q54GH2 | Q869N9 | Probable basic-leucine zipper transcription factor R; Probable transcriptional regulator; Belongs to the bZIP family. | Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] | 0.707 |
bzpR | ifkB | Q54GH2 | Q550L8 | Probable basic-leucine zipper transcription factor R; Probable transcriptional regulator; Belongs to the bZIP family. | Probable serine/threonine-protein kinase ifkB; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.784 |
bzpR | ifkC | Q54GH2 | Q75JN1 | Probable basic-leucine zipper transcription factor R; Probable transcriptional regulator; Belongs to the bZIP family. | Probable serine/threonine-protein kinase ifkC; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.791 |
eif2a | eif2s1 | Q54PV7 | Q869N9 | Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. | Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] | 0.584 |
eif2a | ifkB | Q54PV7 | Q550L8 | Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. | Probable serine/threonine-protein kinase ifkB; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.416 |
eif2a | ifkC | Q54PV7 | Q75JN1 | Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. | Probable serine/threonine-protein kinase ifkC; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.410 |
eif2b1 | eif2s1 | Q54I81 | Q869N9 | Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family. | Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] | 0.999 |
eif2b1 | ifkB | Q54I81 | Q550L8 | Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family. | Probable serine/threonine-protein kinase ifkB; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.438 |
eif2b1 | ifkC | Q54I81 | Q75JN1 | Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family. | Probable serine/threonine-protein kinase ifkC; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.435 |
eif2s1 | bzpR | Q869N9 | Q54GH2 | Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] | Probable basic-leucine zipper transcription factor R; Probable transcriptional regulator; Belongs to the bZIP family. | 0.707 |
eif2s1 | eif2a | Q869N9 | Q54PV7 | Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] | Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. | 0.584 |
eif2s1 | eif2b1 | Q869N9 | Q54I81 | Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] | Translation initiation factor eIF-2B subunit alpha; Catalyzes the exchange of eukaryotic initiation factor 2- bound GDP for GTP; Belongs to the eIF-2B alpha/beta/delta subunits family. | 0.999 |
eif2s1 | gcn1 | Q869N9 | Q54WR2 | Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] | eIF-2-alpha kinase activator GCN1; Acts as a positive activator of the gcn2 protein kinase activity in response to amino acid starvation. Forms a complex with eif2ak4/gcn2 on translating ribosomes; during this process, gcn1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of eif2ak4/gcn2, and hence stimulating eif2ak4/gcn2 kinase activity. Participates in the repression of global protein synthesis and in gene- specific mRNA translation activation, such as the transcriptional activator atf4, by promoting [...] | 0.717 |
eif2s1 | ifkB | Q869N9 | Q550L8 | Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] | Probable serine/threonine-protein kinase ifkB; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.991 |
eif2s1 | ifkC | Q869N9 | Q75JN1 | Eukaryotic translation initiation factor 2 subunit 1; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyz [...] | Probable serine/threonine-protein kinase ifkC; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. | 0.977 |