STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
serpProbable stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation (By similarity); Belongs to the RAMP4 family. (59 aa)    
Predicted Functional Partners:
rckA
RGS domain-containing serine/threonine-protein kinase A; Serine/threonine kinase involved in negative regulation of chemotaxis.
      
 0.817
sec61b
Protein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum.
   
 
 0.680
sgt
Small glutamine-rich tetratricopeptide repeat-containing protein; May act as a co-chaperone and regulate the ATPase activity of heat shock proteins.
    
  0.520
DDB_G0280783
UPF0235 protein; Belongs to the UPF0235 family.
      
 0.489
sec61g
Protein transport protein Sec61 subunit gamma; Necessary for protein translocation in the endoplasmic reticulum.
   
 
  0.461
syn5
t-SNARE family protein.
     
 0.429
ube2j2
Ubiquitin-conjugating enzyme E2 J2; Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum; Belongs to the ubiquitin-conjugating enzyme family.
     
 0.423
cyb5B
Cytochrome b5 B; Belongs to the cytochrome b5 family.
     
 0.418
comG
Aldehyde dehydrogenase family 3 comG.
     
  0.400
sybB
Synaptobrevin-B; Involved in the targeting and/or fusion of transport vesicles to their target membrane; Belongs to the synaptobrevin family.
     
  0.400
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.