STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB_G0274613Probable inactive serine/threonine-protein kinase DDB_G0274613. (831 aa)    
Predicted Functional Partners:
mekA
Dual specificity mitogen-activated protein kinase kinase 1; Required for cAMP-mediated activation of guanylyl cyclase activity and plays an essential role in aggregation, morphogenesis, and chemotaxis. Appears to act upstream of erk1 but not erk2.
   
 
0.654
DDB0216403
Heat shock factor (HSF)-type DNA-binding domain-containing protein.
   
 
 0.565
rps30-1
40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.
    
 
 0.469
rps16
40S ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family.
    
   0.465
ptpC
Tyrosine-protein phosphatase 3; Seems to dephosphorylate a protein of 130 kDa (p130).
   
 
 0.462
DDB0218432
Uncharacterized protein.
    
 
 0.456
gpbA
Guanine nucleotide-binding protein subunit beta; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). Required for normal chemotaxis in response to cAMP and for aggregation during scorocarp development.
   
 
 0.447
bzpO
Probable basic-leucine zipper transcription factor O; Probable transcriptional regulator; Belongs to the bZIP family.
   
 
 0.435
bzpK
Probable basic-leucine zipper transcription factor K; Probable transcriptional regulator; Belongs to the bZIP family.
    
 
 0.429
bzpF
Probable basic-leucine zipper transcription factor F; Probable transcriptional regulator; Belongs to the bZIP family.
    
 
 0.429
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.