hspE-1 protein (Dictyostelium discoideum) - STRING interaction network

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Score

hspE-1

Heat shock cognate 70 kDa protein 2; May function in protein folding and assembly, and disassembly of protein complexes. (632 aa)

Predicted Functional Partners:

dnaja1

0.849

ddj1

0.843

hspD

0.799

bip1-1

0.791

DDB0188683

0.757

DDB0204986

0.756

grpE

0.748

DDB0190510

0.732

DDB0206576

0.730

DDB0215234

0.728

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB0188683	bip1-1	Q54GP6	Q556U6	J domain-containing protein.	Luminal-binding protein 1; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER; Belongs to the heat shock protein 70 family.	0.913
DDB0188683	grpE	Q54GP6	Q54QF9	J domain-containing protein.	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	0.585
DDB0188683	hspD	Q54GP6	P54651	J domain-containing protein.	Heat shock cognate 90 kDa protein; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family.	0.515
DDB0188683	hspE-1	Q54GP6	Q557E0	J domain-containing protein.	Heat shock cognate 70 kDa protein 2; May function in protein folding and assembly, and disassembly of protein complexes.	0.757
DDB0190510	bip1-1	Q55D98	Q556U6	Uncharacterized protein.	Luminal-binding protein 1; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER; Belongs to the heat shock protein 70 family.	0.899
DDB0190510	grpE	Q55D98	Q54QF9	Uncharacterized protein.	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	0.764
DDB0190510	hspD	Q55D98	P54651	Uncharacterized protein.	Heat shock cognate 90 kDa protein; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family.	0.681
DDB0190510	hspE-1	Q55D98	Q557E0	Uncharacterized protein.	Heat shock cognate 70 kDa protein 2; May function in protein folding and assembly, and disassembly of protein complexes.	0.732
DDB0204986	bip1-1	Q54RY0	Q556U6	J domain-containing protein.	Luminal-binding protein 1; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER; Belongs to the heat shock protein 70 family.	0.874
DDB0204986	ddj1	Q54RY0	Q54VQ1	J domain-containing protein.	Heat shock protein.	0.436
DDB0204986	dnaja1	Q54RY0	Q54ED3	J domain-containing protein.	DnaJ homolog subfamily A member 1 homolog; Co-chaperone for Hsp70 family members. Plays a role in protein transport into mitochondria and in the regulation of apoptosis via its role as co-chaperone (By similarity).	0.432
DDB0204986	grpE	Q54RY0	Q54QF9	J domain-containing protein.	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	0.585
DDB0204986	hspD	Q54RY0	P54651	J domain-containing protein.	Heat shock cognate 90 kDa protein; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family.	0.497
DDB0204986	hspE-1	Q54RY0	Q557E0	J domain-containing protein.	Heat shock cognate 70 kDa protein 2; May function in protein folding and assembly, and disassembly of protein complexes.	0.756
DDB0206576	bip1-1	Q86KX9	Q556U6	J domain-containing protein.	Luminal-binding protein 1; Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER; Belongs to the heat shock protein 70 family.	0.859
DDB0206576	ddj1	Q86KX9	Q54VQ1	J domain-containing protein.	Heat shock protein.	0.427
DDB0206576	dnaja1	Q86KX9	Q54ED3	J domain-containing protein.	DnaJ homolog subfamily A member 1 homolog; Co-chaperone for Hsp70 family members. Plays a role in protein transport into mitochondria and in the regulation of apoptosis via its role as co-chaperone (By similarity).	0.429
DDB0206576	grpE	Q86KX9	Q54QF9	J domain-containing protein.	GrpE protein homolog, mitochondrial; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity).	0.585
DDB0206576	hspD	Q86KX9	P54651	J domain-containing protein.	Heat shock cognate 90 kDa protein; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity); Belongs to the heat shock protein 90 family.	0.497
DDB0206576	hspE-1	Q86KX9	Q557E0	J domain-containing protein.	Heat shock cognate 70 kDa protein 2; May function in protein folding and assembly, and disassembly of protein complexes.	0.730