STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB_G0271356LIM domain-containing protein DDB_G0271356. (186 aa)    
Predicted Functional Partners:
ctnnA
Probable vinculin; Involved in cell adhesion. Thought to play an important role in cytokinesis B, probably by providing substrate adhesion and traction forces. Required to organize and polarize the tip epithelium during cytokinesis. Required for the normal distribution of myosin in the tip epithelium. Involved in the localization of ctxA, ctxB, dcsA, exoc6 and rgaA. Thought to form a complex with ctxA, ctxB, and rgaA which regulates myosin accumulation to the apical plasma membrane. Belongs to the vinculin/alpha-catenin family.
   
 
 0.987
talB
Talin-B; Actin-binding protein required for multicellular morphogenesis. Substrate of pkgB and/or pkbA.
  
 
 0.982
vasp
Protein VASP homolog; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as lamellipodial and filopodial dynamics in migrating cells. Plays a crucial role in filopodia formation, cell-substratum adhesion, and proper chemotaxis. Nucleates and bundles actin filaments. When complexed with fotH in filopodial tips, may support formin- mediated filament elongation by bundling nascent actin filaments. Belongs to the Ena/VASP family.
   
  
 0.702
abpC
Gelation factor; F-actin cross-linking protein.
   
 
 0.599
racQ
Rho GTPase.
    
 
 0.597
racL
Rho-related protein racL.
    
 
 0.578
racE
Rho-related protein racE; Specifically required for cytokinesis; Belongs to the small GTPase superfamily. Rho family.
   
 
 0.569
racO
Rho-related protein racO.
   
 
 0.566
RacP
Rho GTPase.
    
 
 0.564
racN
Rho-related protein racN.
    
 
 0.564
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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