STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0190543UBX domain-containing protein. (264 aa)    
Predicted Functional Partners:
ubxd7
UBX domain-containing protein 7 homolog.
    
 
 0.887
ufd1
Ubiquitin fusion degradation protein 1 homolog; Functions at a post-ubiquitation step in the ubiquitin fusion degradation (UFD) pathway; Belongs to the UFD1 family.
    
 
 0.813
nploc4
Nuclear protein localization protein 4 homolog; May be part of a complex that binds ubiquitinated proteins and that is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. Belongs to the NPL4 family.
   
 
 0.807
DDB0217687
PRKCSH domain-containing protein.
    
 
 0.728
DDB0189206
Uncharacterized protein.
   
 
 0.710
DDB0169455
Uncharacterized protein.
   
 
 0.617
DDB0206533
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 
 0.593
DDB0205698
TUG-UBL1 domain-containing protein.
    
 
 0.593
nsfl1c
NSFL1 cofactor p47 homolog; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity).
    
 
 0.555
derl1
Probable derlin-1 homolog; May be involved in the degradation process of specific misfolded endoplasmic reticulum (ER) luminal proteins. May also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. Belongs to the derlin family.
   
 
 0.553
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.