STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0189736Uncharacterized protein. (617 aa)    
Predicted Functional Partners:
ppp6c
Serine/threonine-protein phosphatase 6 catalytic subunit.
    
 0.945
cnrM
Ankyrin repeat-containing protein.
    
  0.549
pho2a
Serine/threonine-protein phosphatase 2A catalytic subunit A; Plays a role in activating the myosin contractile function. Dephosphorylates threonine at 'Thr-1823', 'Thr-1833' and 'Thr-2029' in the C-terminal tail region of myosin II heavy chain (mhcA). Drives the assembly of dephosphorylated myosin II filaments to allow myosin recruitment into the cytoskeleton.
   
 
 0.527
pho2B
Protein phosphatase 2A catalytic subunit B; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway ; Belongs to the PPP phosphatase family. PP-2A subfamily.
    
 
 0.490
ppp4c
Serine/threonine-protein phosphatase 4 catalytic subunit; Required for development, chemotaxis and the expression of numerous genes.
    
 
 0.490
pppB
Serine/threonine-protein phosphatase PP1; Protein phosphatase activity in vitro.
   
 
 0.458
DDB0205063
Uncharacterized protein.
    
 
 0.449
canA
Serine/threonine-protein phosphatase 2B catalytic subunit; Catalytic subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Belongs to the PPP phosphatase family. PP-2B subfamily.
    
 
 0.449
psmB6
Proteasome subunit beta type-6; The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
 
      0.447
sec24l
Uncharacterized protein.
   
 
  0.410
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.