STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0189484SCP domain-containing protein. (551 aa)    
Predicted Functional Partners:
H2AZ
Histone H2A.z; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
   
 
 0.585
Rvb1
RuvB-like helicase; Belongs to the RuvB family.
    
 
 0.578
znhit1
Zinc finger HIT domain-containing protein 1 homolog; Belongs to the ZNHIT1 family.
    
 
 0.575
DDB0188089
SANT domain-containing protein.
   
 
 0.570
DDB0191982
YL1_C domain-containing protein.
    
 
 0.564
rvb2
RuvB-like helicase 2; Has double-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription.
   
 
 0.562
ArpD
Uncharacterized protein; Belongs to the actin family.
    
 
 0.556
DDB0217507
Uncharacterized protein.
    
 
 0.554
DDB0168053
BCNT-C domain-containing protein.
    
 
 0.487
tra1
Probable transcription-associated protein 1; Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
   
 
 0.465
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.