STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
alrAAldose reductase A; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies (By similarity). Probably affects several metabolic pathways in addition to converting glucose to sorbitol. Affects group size; Belongs to the aldo/keto reductase family. (297 aa)    
Predicted Functional Partners:
DDB_G0276821
Putative aldehyde dehydrogenase family 7 member A1 homolog; Belongs to the aldehyde dehydrogenase family.
 
 
 0.954
DDB0231475
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
 
 
 0.954
DDB0231474
Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.
 
 
 0.954
qdpr
Dihydropteridine reductase; The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
 0.915
DDB0230113
Dihydrofolate reductase.
  
 
 0.912
sprA
Sepiapterin reductase; Catalyzes the production of D-threo-tetrahydrobiopterin (DH4), also known as dictyopterin, and in a much smaller amount that of it's stereoisomer L-erythro-tetrahydrobiopterin (BH4). Prefers 1-oxo-2- D-hydroxypropyl-tetrahydropterin to 6-pyruvoyltetrahydropterin as a substrate, thereby maintaining dominant production of DH4 over BH4 in sufficient supply of an aldose reductase-like enzyme. DH4 represents more than 95% of the total tetrahydrobiopterin production. It has a direct antioxidant function to protect mitochondria against oxidative stress.
  
 
  0.910
gk
Probable glycerol kinase; Belongs to the FGGY kinase family.
  
 
 0.909
glb1
Beta-galactosidase 1; Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.
  
 
  0.903
alrC
Aldose reductase C; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
  
  
 
0.903
alrB
Aldose reductase B; Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
  
  
 
0.902
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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