STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pole3DNA polymerase epsilon subunit 3; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). Forms a complex with CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of iswi/snf2h and acf1 (By similarity). (138 aa)    
Predicted Functional Partners:
pole
DNA polymerase epsilon catalytic subunit A; DNA polymerase II participates in chromosomal DNA replication.
   
 0.999
pole2
DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity).
    
 0.997
DDB0216394
Putative histone-like transcription factor.
    
 0.997
Isw
Uncharacterized protein.
    
 0.936
pola1
DNA polymerase alpha catalytic subunit; Polymerase alpha in a complex with DNA primase is a replicative polymerase; Belongs to the DNA polymerase type-B family.
   
 0.935
DDB_G0282237
DDT domain-containing protein DDB_G0282237.
    
 
 0.926
pold1
DNA polymerase delta catalytic subunit; Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.
   
 0.925
PolZ
Uncharacterized protein.
   
 0.920
nfyc-1
Nuclear transcription factor Y subunit gamma; Stimulates the transcription of various genes by recognizing and binding to a CCAAT motif in promoters.
    
 
 0.897
DDB_G0268506
CBFD_NFYB_HMF domain-containing protein.
    
 
 0.897
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.