STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0217806Rap-GAP domain-containing protein. (855 aa)    
Predicted Functional Partners:
rapA
Ras-related protein rapA; G protein of the Ras family that positively regulates phagocytosis and negatively regulates macropinocytosis. May be involved in the activation of guanylyl cyclase during the response to hyperosmotic conditions. Overexpressing cells generate alterations in cell shape and contractile responses. Involved in chemotaxis via regulation of the balance of Ras and Rap signaling at the leading edge of chemotaxing cells.
  
 
  0.656
gefD
Ras guanine nucleotide exchange factor D; Promotes the exchange of Ras-bound GDP by GTP.
  
  
  0.623
fttB
14-3-3-like protein; Belongs to the 14-3-3 family.
    
  0.531
DDB_G0291510
GTPase-activating protein DDB_G0291510.
  
  
 
0.513
gefN
Ras guanine nucleotide exchange factor N; Promotes the exchange of Ras-bound GDP by GTP (By similarity). May play a role in chemotaxis.
     
  0.499
gefC
Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP.
     
  0.499
gefM
Ras guanine nucleotide exchange factor M; Promotes the exchange of Ras-bound GDP by GTP.
     
  0.499
rapgap1
RapA guanosine triphosphatase-activating protein 1; Mediates the deactivation of rap1 and plays an important role in spatially and temporally regulating cell adhesion and chemotaxis by controlling attachment disassembly in the leading edge through the regulation of myosin II assembly and disassembly. Overexpression leads to defective chemotaxis.
   
 
 
0.415
pkaC
cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis.
   
 
  0.403
pkaD
Developmentally-regulated protein kinase 1.
   
 
  0.401
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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