STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0167572USP domain-containing protein; Belongs to the peptidase C19 family. (1258 aa)    
Predicted Functional Partners:
cdc20
Anaphase-promoting complex subunit cdc20; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle; Belongs to the WD repeat CDC20/Fizzy family.
   
 
 0.705
gtaT
GATA zinc finger domain-containing protein 20.
   
 
  0.704
ubpA
Ubiquitin carboxyl-terminal hydrolase A; Required for development but not growth. Belongs to the peptidase C19 family.
      
 0.641
Usp39
SAP DNA-binding domain-containing protein.
   
  
0.578
DDB0205750
OTU domain-containing protein.
   
  
 0.559
DG1039
Probable ubiquitin thioesterase DG1039; May be a zinc metalloprotease that specifically cleaves ubiquitin chains.
   
  
 0.552
H2Av2
Histone H2A.v2; Belongs to the histone H2A family.
   
  0.540
H2AX
Histone H2AX; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Phosphorylation of H2AX seems to be performed by atr1 an [...]
   
  0.540
H2Av3
Histone H2A.v3; Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).
    
  0.537
H2Av1
Histone H2A.v1; Belongs to the histone H2A family.
    
  0.537
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.