node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDB0189538 | gefI | Q55G82 | Q8IS15 | Uncharacterized protein. | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. | 0.450 |
gefC | gefI | Q8IS20 | Q8IS15 | Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. | 0.502 |
gefC | rasD | Q8IS20 | P03967 | Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.919 |
gefC | rasG | Q8IS20 | P15064 | Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. | Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.903 |
gefC | scaA | Q8IS20 | Q54XY4 | Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. | 0.797 |
gefI | DDB0189538 | Q8IS15 | Q55G82 | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. | Uncharacterized protein. | 0.450 |
gefI | gefC | Q8IS15 | Q8IS20 | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. | Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. | 0.502 |
gefI | rasD | Q8IS15 | P03967 | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.510 |
gefI | rasG | Q8IS15 | P15064 | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. | Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.481 |
gefI | scaA | Q8IS15 | Q54XY4 | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. | 0.443 |
rasD | gefC | P03967 | Q8IS20 | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. | 0.919 |
rasD | gefI | P03967 | Q8IS15 | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. | 0.510 |
rasD | rasG | P03967 | P15064 | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.618 |
rasD | scaA | P03967 | Q54XY4 | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. | 0.537 |
rasG | gefC | P15064 | Q8IS20 | Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. | 0.903 |
rasG | gefI | P15064 | Q8IS15 | Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. | 0.481 |
rasG | rasD | P15064 | P03967 | Ras-like protein rasG; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.618 |
scaA | gefC | Q54XY4 | Q8IS20 | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. | Ras guanine nucleotide exchange factor C; Promotes the exchange of Ras-bound GDP by GTP. | 0.797 |
scaA | gefI | Q54XY4 | Q8IS15 | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. | Ras guanine nucleotide exchange factor I; Promotes the exchange of Ras-bound GDP by GTP. | 0.443 |
scaA | rasD | Q54XY4 | P03967 | Sca1 complex scaffold protein scaA; Component of the Sca1 complex, a regulator of cell motility, chemotaxis and signal relay. The Sca1 complex is recruited to the plasma membrane in a chemoattractant- and F-actin- dependent manner and is enriched at the leading edge of chemotaxing cells where it regulates F-actin dynamics and signal relay by controlling the activation of rasC and the downstream target of rapamycin complex 2 (TORC2)-Akt/protein kinase B (PKB) pathway. ScaA acts as a molecular scaffold, bringing together gefA, gefH and phr with PP2A. | Ras-like protein rasD; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. | 0.537 |