STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdeEcAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase B; Dual specificity cAMP and cGMP phosphodiesterase with marked preference for cyclic AMP, which is activated by cAMP and cGMP. Likely functions as a cAMP-stimulated cAMP-phosphodiesterase which may play a role in regulating the cAMP relay response. Belongs to the metallo-beta-lactamase superfamily. cNMP phosphodiesterase family. (1096 aa)    
Predicted Functional Partners:
pkaC
cAMP-dependent protein kinase catalytic subunit; Essential for differentiation and fruit morphogenesis.
   
 0.884
pkaD
Developmentally-regulated protein kinase 1.
   
 0.884
regA
3',5'-cyclic-nucleotide phosphodiesterase regA; Phosphodiesterase specific for cAMP. Involved in the degradation of intracellular cAMP. Morphological suppressor of tagB. Phosphorelay protein that accepts phosphate from rdeA or supplies phosphate from regA; depending on the relative concentration of the phosphodonor proteins; Belongs to the cyclic nucleotide phosphodiesterase family.
   
 
 0.828
pde3
cGMP-specific 3',5'-cGMP phosphodiesterase 3; Phosphodiesterase specific for cGMP, which is not activated by cGMP. Involved in the degradation of intracellular cGMP.
   
 
 0.762
fdxr
Probable NADPH:adrenodoxin oxidoreductase, mitochondrial.
  
 
 0.734
argC
N-acetyl-gamma-glutamyl-phosphate reductase; In the C-terminal section; belongs to the NAGSA dehydrogenase family.
     
 0.733
pde7
cAMP/cGMP-dependent 3',5'-cAMP/cGMP phosphodiesterase 7; Phosphodiesterase with dual cAMP/cGMP specificity. However, displays a preference for cAMP over cGMP. Seems to regulate cAMP/cGMP concentration especially during cell aggregation.
    
 
 0.728
dr1
Protein Dr1 homolog; Involved in transcriptional regulation. Component of the NC2 complex which represses RNA polymerase II transcription through binding to tbp and thereby inhibiting the assembly of the preinitiation complex (By similarity).
      
 0.725
gbpD
Cyclic GMP-binding protein D; Promotes the exchange of Ras-bound GDP by GTP (By similarity). Induces the formation of substrate-attached pseudopodia, that leads to increased adhesion and thereby negatively influencing cell speed and polarity.
      
 0.701
DDB0186653
GSAP-16 domain-containing protein.
   
 
 0.669
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.