STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
amtCAmmonium transporter 3; Ammonium transporter that mediates the import of ammonium in prespore cells. Controls ammonium homeostasis during growth and development. Ammonium has been shown to function as a morphogen at multiple steps during the development. May function as an ammonia sensor that relays information concerning ammonia concentrations to the signaling pathway involved in the slug versus culmination choice and regulates prestalk gene expression. (431 aa)    
Predicted Functional Partners:
dhkC
Hybrid signal transduction histidine kinase C; Acts in a signal transduction pathway that regulates the slug versus culmination choice. Believed to be the first component of a phosphorelay that couples the sensing of ammonia to the modulation of PKA activity and hence activates culmination and spore germination. Ammonium transporters amtA and amtC are thought to respectively activate and inhibit dhkC phosphorelay. This protein probably undergoes an ATP-dependent autophosphorylation at conserved His residue in the kinase core, and a phosphoryl group is then transferred to a conserved as [...]
 
 
 
 0.797
ach1
Acetyl-CoA hydrolase; Presumably involved in regulating the intracellular acetyl- CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.
     
 0.780
rhgB
Rhesus-like glycoprotein B; May be a carbon dioxide/bicarbonate transporter. Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.
   
  
 0.733
glnA1
Type-1 glutamine synthetase 1.
  
  
 0.726
DDB0219593
Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.
   
  
 0.710
DDB0205543
Uncharacterized protein.
   
  
 0.710
dstA
Signal transducer and activator of transcription A; Transcription factor that binds to 5'-TTGAATTGA-3' elements in the promoter region of target genes. Functions as repressor of the ecmB gene. Regulates the differentiation of prestalk cells during development.
      
 0.618
argC
N-acetyl-gamma-glutamyl-phosphate reductase; In the C-terminal section; belongs to the NAGSA dehydrogenase family.
     
 0.567
DDB_G0287281
Citrate synthase-related protein DDB_G0287281; Belongs to the citrate synthase family.
   
  
 0.504
cs
Citrate synthase, mitochondrial; Belongs to the citrate synthase family.
   
  
 0.504
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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