STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DDB0168634RED_N domain-containing protein. (714 aa)    
Predicted Functional Partners:
smu1
WD40 repeat-containing protein smu1; Involved in pre-mRNA splicing as a component of the spliceosome.
   
 
 0.995
mfap1
Protein MFAP1 homolog; Involved in pre-mRNA splicing as a component of the spliceosome.
   
   0.836
Eftud2
Tr-type G domain-containing protein.
   
 
 0.828
DDB_G0280363
TPR-containing protein DDB_G0280363.
   
 
 0.801
Prpf6
TPR_REGION domain-containing protein.
   
 
 0.801
Prpf38a
Uncharacterized protein.
   
 
 0.720
snrnp40
U5 small nuclear ribonucleoprotein 40 kDa protein; Required for pre-mRNA splicing as component of the activated spliceosome. Component of the U5 small nuclear ribonucleoprotein (snRNP) complex and the U4/U6-U5 tri-snRNP complex, building blocks of the spliceosome.
    
 
 0.715
sf3b3
Probable splicing factor 3B subunit 3; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nucle [...]
   
   0.663
Prpf3
Uncharacterized protein.
   
   0.659
DDB0190983
Uncharacterized protein.
    
   0.658
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.