STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
arsAATPase ASNA1 homolog; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for ins [...] (329 aa)    
Predicted Functional Partners:
DDB_G0281815
Golgi to ER traffic protein 4 homolog; May play a role in insertion of tail-anchored proteins into the endoplasmic reticulum membrane.
   
 
 0.995
acp1
Low molecular weight phosphotyrosine protein phosphatase; Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates; Belongs to the low molecular weight phosphotyrosine protein phosphatase family.
    
 0.931
arsB
Putative transporter arsB.
    
 0.914
rcbA
UV excision repair protein RAD23 homolog; May play a role both in proteasomal degradation of misfolded proteins and DNA repair; Belongs to the RAD23 family.
   
 
 0.874
syn5
t-SNARE family protein.
   
 
 0.788
DDB_G0269942
Uncharacterized protein; Belongs to the synaptobrevin family.
   
 
 0.770
sgt
Small glutamine-rich tetratricopeptide repeat-containing protein; May act as a co-chaperone and regulate the ATPase activity of heat shock proteins.
   
 
 0.716
DDB0190877
Uncharacterized protein.
   
 
 0.710
DDB0185786
Ubiquitin-like domain-containing protein.
    
 
 0.693
pex6
Peroxisomal biogenesis factor 6; Required for biogenesis of peroxisomes; Belongs to the AAA ATPase family.
  
 
 0.671
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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