alxA protein (Dictyostelium discoideum) - STRING interaction network

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Score

alxA

ALG-2 interacting protein X; Unknown. Required for development but not for cell death. (794 aa)

Predicted Functional Partners:

chmp4

0.996

tsg101

0.902

vps28

0.812

DDB0206193

0.812

chmp1

0.732

chmp6

0.705

pefB

0.640

chmp3

0.630

vps36

0.622

pefA

0.618

Your Current Organism:

Dictyostelium discoideum

NCBI taxonomy Id: 44689
Other names: D. discoideum

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDB0206193	alxA	Q54XR6	Q8T7K0	Uncharacterized protein.	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	0.812
alxA	DDB0206193	Q8T7K0	Q54XR6	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	Uncharacterized protein.	0.812
alxA	chmp1	Q8T7K0	O96552	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	Charged multivesicular body protein 1; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	0.732
alxA	chmp3	Q8T7K0	Q54P63	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	0.630
alxA	chmp4	Q8T7K0	Q86H98	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	Charged multivesicular body protein 4; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins.	0.996
alxA	chmp6	Q8T7K0	Q54KZ4	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	0.705
alxA	pefA	Q8T7K0	Q95YL5	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	Penta-EF hand domain-containing protein 1; Belongs to the Peflin/Sorcin family.	0.618
alxA	pefB	Q8T7K0	Q95YL4	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	Penta-EF hand domain-containing protein 2; Belongs to the Peflin/Sorcin family.	0.640
alxA	tsg101	Q8T7K0	Q54LJ3	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	ESCRT-I complex subunit tsg101; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Acts as a negative growth regulator (By similarity); Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.	0.902
alxA	vps28	Q8T7K0	Q54NF1	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex, a regulator of vesicular trafficking process.	0.812
alxA	vps36	Q8T7K0	Q54T18	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (By similarity).	0.622
chmp1	alxA	O96552	Q8T7K0	Charged multivesicular body protein 1; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	0.732
chmp1	chmp3	O96552	Q54P63	Charged multivesicular body protein 1; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	0.997
chmp1	chmp4	O96552	Q86H98	Charged multivesicular body protein 1; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	Charged multivesicular body protein 4; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins.	0.985
chmp1	chmp6	O96552	Q54KZ4	Charged multivesicular body protein 1; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	0.895
chmp1	tsg101	O96552	Q54LJ3	Charged multivesicular body protein 1; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	ESCRT-I complex subunit tsg101; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. Acts as a negative growth regulator (By similarity); Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.	0.945
chmp1	vps28	O96552	Q54NF1	Charged multivesicular body protein 1; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	Vacuolar protein sorting-associated protein 28; Component of the ESCRT-I complex, a regulator of vesicular trafficking process.	0.920
chmp1	vps36	O96552	Q54T18	Charged multivesicular body protein 1; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	Vacuolar protein-sorting-associated protein 36; Component of the ESCRT-II complex, which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation (By similarity).	0.954
chmp3	alxA	Q54P63	Q8T7K0	Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	ALG-2 interacting protein X; Unknown. Required for development but not for cell death.	0.630
chmp3	chmp1	Q54P63	O96552	Charged multivesicular body protein 3; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	Charged multivesicular body protein 1; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and are delivered to lysosomes enabling degradation of membrane proteins (By similarity).	0.997