STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cprGCysteine proteinase 7. (460 aa)    
Predicted Functional Partners:
ctsD
Cathepsin D; Protease that may act during cell growth and/or development; Belongs to the peptidase A1 family.
 
 
 0.823
DDB0187993
Pept_C1 domain-containing protein; Belongs to the peptidase C1 family.
  
  
0.650
cprD
Cysteine proteinase 4.
  
0.569
DDB0219654
Uncharacterized protein; Belongs to the peptidase C1 family.
  
0.557
cprA
Cysteine proteinase 1; Cysteine proteinases 1 and 2 are believed to participate in the breakdown of protein during differentiation of Dictyostelium as a response to starvation.
  
0.555
hexa2
Beta-hexosaminidase subunit A2; Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines.
     
 0.545
cfaD
Counting factor associated protein D; Inhibitor that slows proliferation of secreting cells (also known as chalone). Requires aprA for activity.
  
 
0.544
cpiC
Cystatin-A3; Intracellular thiol proteinase inhibitor; Belongs to the cystatin family.
   
 0.517
cpiB
Cystatin-A2; Intracellular thiol proteinase inhibitor. Inhibits cathepsin B, but not papain.
   
 0.517
cpiA
Cystatin-A1; Intracellular thiol proteinase inhibitor. Inhibits papain, but not cathepsin B.
   
 0.517
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.