STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spc98Spindle pole body component 98; May be involved in microtubule nucleation. (813 aa)    
Predicted Functional Partners:
tubC
Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly (By similarity).
   
 0.999
spc97
Spindle pole body component 97; May be involved in microtubule nucleation; Belongs to the TUBGCP family.
  
0.998
acad8
Isobutyryl-CoA dehydrogenase, mitochondrial; Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA.
   
 
 0.888
sun1
Sun domain-containing protein 1; May have an important role in defining the spacing of the nuclear envelope lumen. Essential for centrosome attachment to the nucleus, maintenance of correct ploidy, proper mitosis, association of the centromere cluster with the centrosome and the maintenance of genome stability. Requires direct chromatin binding for inner nuclear membrane targeting.
   
 
 0.793
mtaA
Centrosomal protein 224; Involved in regulation of microtubule dynamics. Regulates the interaction of microtubules tips with the centrosome and cell cortex.
    
 
 0.746
DDB0189713
DAO domain-containing protein.
    
 
 0.733
kif13
Kinesin-related protein 13; Microtubule-associated force-producing protein that plays a role in organelle transport. Its motor activity is directed toward the microtubule's plus end (By similarity). Cooperates with dynein to control the spindle elongation rate, but is dispensable for mitosis. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.
   
 
 0.725
porA
Mitochondrial outer membrane protein porin; Forms a channel of about 1,7 nM through the cell membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 20 mv. The open state has a weak anion selectivity whereas the closed state is cation-selective.
      
 0.707
DDB0205745
Uncharacterized protein.
    
 
 0.692
arpE
Actin-related protein 5; Proposed core component of the chromatin remodeling Ino80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
   
   0.676
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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