STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cmfBConditioned medium factor receptor 1; Receptor for cmfA, that appears to mediate the G-independent cmfA signal transduction. (510 aa)    
Predicted Functional Partners:
erg2
Protein erg2 homolog; May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity); Belongs to the ERG2 family.
   
 
 0.906
cas1
Cycloartenol synthase; Converts oxidosqualene to cycloartenol (in vitro); Belongs to the terpene cyclase/mutase family.
   
 
 0.903
fdfT
Squalene synthase.
   
 
 0.900
cyp51
Probable lanosterol 14-alpha demethylase; Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'- dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity).
   
 0.872
DDB0205936
Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family.
   
 
 0.834
DDB_G0270946
Putative methylsterol monooxygenase DDB_G0270946.
   
 
 0.834
DDB_G0269788
Putative methylsterol monooxygenase DDB_G0269788.
   
 
 0.834
ipi
Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
   
  
 0.766
cmfA
Conditioned medium factor; Involved in cell density sensing and might synchronize the onset of development by triggering aggregation when a majority of the cells in a given area have starved.
      
 0.723
hgsA
Hydroxymethylglutaryl-CoA synthase A; Condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
   
  
 0.701
Your Current Organism:
Dictyostelium discoideum
NCBI taxonomy Id: 44689
Other names: D. discoideum
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