node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHM10096.1 | SHM10127.1 | SAMN05660826_00235 | SAMN05660826_00236 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | DNA processing protein. | 0.723 |
SHM10096.1 | SHM44789.1 | SAMN05660826_00235 | SAMN05660826_01054 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Uroporphyrinogen III methyltransferase / synthase. | 0.749 |
SHM10096.1 | SHM44973.1 | SAMN05660826_00235 | SAMN05660826_01060 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Cobalt-precorrin 4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.718 |
SHM10096.1 | SHM83730.1 | SAMN05660826_00235 | SAMN05660826_02109 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Adenosylcobinamide kinase. | 0.944 |
SHM10096.1 | SHM88356.1 | SAMN05660826_00235 | SAMN05660826_02241 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | ATP:cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.947 |
SHM10096.1 | cbiA | SAMN05660826_00235 | SAMN05660826_01067 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.945 |
SHM10096.1 | cobD | SAMN05660826_00235 | SAMN05660826_02112 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.920 |
SHM10096.1 | cobQ | SAMN05660826_00235 | SAMN05660826_00994 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.982 |
SHM10096.1 | cobS | SAMN05660826_00235 | SAMN05660826_02113 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.940 |
SHM10096.1 | topA | SAMN05660826_00235 | SAMN05660826_00237 | cob(I)yrinic acid a,c-diamide adenosyltransferase. | DNA topoisomerase-1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.707 |
SHM10127.1 | SHM10096.1 | SAMN05660826_00236 | SAMN05660826_00235 | DNA processing protein. | cob(I)yrinic acid a,c-diamide adenosyltransferase. | 0.723 |
SHM10127.1 | topA | SAMN05660826_00236 | SAMN05660826_00237 | DNA processing protein. | DNA topoisomerase-1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.965 |
SHM44789.1 | SHM10096.1 | SAMN05660826_01054 | SAMN05660826_00235 | Uroporphyrinogen III methyltransferase / synthase. | cob(I)yrinic acid a,c-diamide adenosyltransferase. | 0.749 |
SHM44789.1 | SHM44973.1 | SAMN05660826_01054 | SAMN05660826_01060 | Uroporphyrinogen III methyltransferase / synthase. | Cobalt-precorrin 4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.970 |
SHM44789.1 | SHM83730.1 | SAMN05660826_01054 | SAMN05660826_02109 | Uroporphyrinogen III methyltransferase / synthase. | Adenosylcobinamide kinase. | 0.757 |
SHM44789.1 | SHM88356.1 | SAMN05660826_01054 | SAMN05660826_02241 | Uroporphyrinogen III methyltransferase / synthase. | ATP:cob(I)alamin adenosyltransferase; Belongs to the Cob(I)alamin adenosyltransferase family. | 0.671 |
SHM44789.1 | cbiA | SAMN05660826_01054 | SAMN05660826_01067 | Uroporphyrinogen III methyltransferase / synthase. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.956 |
SHM44789.1 | cobD | SAMN05660826_01054 | SAMN05660826_02112 | Uroporphyrinogen III methyltransferase / synthase. | Adenosylcobinamide-phosphate synthase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.736 |
SHM44789.1 | cobQ | SAMN05660826_01054 | SAMN05660826_00994 | Uroporphyrinogen III methyltransferase / synthase. | Adenosylcobyric acid synthase (glutamine-hydrolysing); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.741 |
SHM44789.1 | cobS | SAMN05660826_01054 | SAMN05660826_02113 | Uroporphyrinogen III methyltransferase / synthase. | Cobalamin-5'-phosphate synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.741 |