Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sfcA_1Malate dehydrogenase. (569 aa)    
Predicted Functional Partners:
pykA
Pyruvate kinase II; Belongs to the pyruvate kinase family.
  
 0.897
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family.
  
 0.888
fumC
Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 
 0.879
korA
2-oxoglutarate ferredoxin oxidoreductase subunit alpha.
     
 0.878
ppsA
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
   
 
 0.864
Lery_1335
Oxaloacetate decarboxylase subunit alpha.
     
 0.862
Lery_2261
2-oxoglutarate ferredoxin oxidoreductase beta subunit.
     
 0.854
Lery_1854
Pyruvate dehydrogenase E1 component oxidoreductase protein AceE; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
    
 0.852
prpC
2-methylcitrate synthase; Belongs to the citrate synthase family.
  
 
 0.851
gltA
Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.851
Your Current Organism:
Legionella erythra
NCBI taxonomy Id: 448
Other names: ATCC 35303, CCUG 29667, CIP 103843, DSM 17644, JCM 7564, L. erythra, NCTC 11977, strain SE-32A-C8
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