node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Lery_0809 | gcsA | Lery_0809 | Lery_0810 | YCII domain-containing protein. | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.800 |
Lery_0809 | gcvH | Lery_0809 | Lery_0811 | YCII domain-containing protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.800 |
Lery_0809 | gcvPB | Lery_0809 | Lery_0808 | YCII domain-containing protein. | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.800 |
Lery_0809 | gcvT | Lery_0809 | Lery_0812 | YCII domain-containing protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.694 |
Lery_1856 | Lery_1939 | Lery_1856 | Lery_1939 | Dihydrolipoamide dehydrogenase. | Hypothetical protein. | 0.546 |
Lery_1856 | folD | Lery_1856 | Lery_1382 | Dihydrolipoamide dehydrogenase. | Bifunctional Methylenetetrahydrofolate dehydrogenase/Methenyltetrahydrofolate cyclohydrolase FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.683 |
Lery_1856 | gcsA | Lery_1856 | Lery_0810 | Dihydrolipoamide dehydrogenase. | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.705 |
Lery_1856 | gcvH | Lery_1856 | Lery_0811 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.875 |
Lery_1856 | gcvPB | Lery_1856 | Lery_0808 | Dihydrolipoamide dehydrogenase. | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.711 |
Lery_1856 | gcvT | Lery_1856 | Lery_0812 | Dihydrolipoamide dehydrogenase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.730 |
Lery_1856 | glyA | Lery_1856 | Lery_0095 | Dihydrolipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.693 |
Lery_1856 | ltaE | Lery_1856 | Lery_2491 | Dihydrolipoamide dehydrogenase. | Low specificity L-threonine aldolase. | 0.519 |
Lery_1856 | thyA | Lery_1856 | Lery_0788 | Dihydrolipoamide dehydrogenase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.657 |
Lery_1939 | Lery_1856 | Lery_1939 | Lery_1856 | Hypothetical protein. | Dihydrolipoamide dehydrogenase. | 0.546 |
Lery_1939 | folD | Lery_1939 | Lery_1382 | Hypothetical protein. | Bifunctional Methylenetetrahydrofolate dehydrogenase/Methenyltetrahydrofolate cyclohydrolase FolD; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.793 |
Lery_1939 | gcsA | Lery_1939 | Lery_0810 | Hypothetical protein. | Glycine dehydrogenase subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.731 |
Lery_1939 | gcvH | Lery_1939 | Lery_0811 | Hypothetical protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.793 |
Lery_1939 | gcvPB | Lery_1939 | Lery_0808 | Hypothetical protein. | Putative glycine dehydrogenase [decarboxylating] subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.783 |
Lery_1939 | gcvT | Lery_1939 | Lery_0812 | Hypothetical protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.822 |
Lery_1939 | glyA | Lery_1939 | Lery_0095 | Hypothetical protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.827 |