pieE protein (Legionella erythra) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

pieE

Substrate of the Dot/Icm secretion system. (575 aa)

Predicted Functional Partners:

map

0.861

rpsN

0.831

dksA

0.765

rpmB

0.723

Lery_0915

0.547

cobN

0.544

rpmG

0.523

hisI

0.493

rpmE

0.436

hemD

0.434

Your Current Organism:

Legionella erythra

NCBI taxonomy Id: 448
Other names: ATCC 35303, CCUG 29667, CIP 103843, DSM 17644, JCM 7564, L. erythra, NCTC 11977, strain SE-32A-C8

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Lery_0915	pieE	Lery_0915	Lery_0916	MAPEG family protein.	Substrate of the Dot/Icm secretion system.	0.547
cobN	hemD	Lery_1658	Lery_1659	Aerobic cobaltochelatase subunit CobN.	uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.	0.730
cobN	pieE	Lery_1658	Lery_0916	Aerobic cobaltochelatase subunit CobN.	Substrate of the Dot/Icm secretion system.	0.544
dksA	pieE	Lery_0444	Lery_0916	DnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.	Substrate of the Dot/Icm secretion system.	0.765
hemD	cobN	Lery_1659	Lery_1658	uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.	Aerobic cobaltochelatase subunit CobN.	0.730
hemD	pieE	Lery_1659	Lery_0916	uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.	Substrate of the Dot/Icm secretion system.	0.434
hisI	map	Lery_0995	Lery_1034	phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	0.954
hisI	pieE	Lery_0995	Lery_0916	phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.	Substrate of the Dot/Icm secretion system.	0.493
hisI	rpmE	Lery_0995	Lery_1514	phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.	50S ribosomal protein L31; Binds the 23S rRNA.	0.916
map	hisI	Lery_1034	Lery_0995	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.	0.954
map	pieE	Lery_1034	Lery_0916	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	Substrate of the Dot/Icm secretion system.	0.861
map	rpmG	Lery_1034	Lery_1319	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.	0.428
map	rpsN	Lery_1034	Lery_1456	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	30S ribosomal protein S14.	0.995
pieE	Lery_0915	Lery_0916	Lery_0915	Substrate of the Dot/Icm secretion system.	MAPEG family protein.	0.547
pieE	cobN	Lery_0916	Lery_1658	Substrate of the Dot/Icm secretion system.	Aerobic cobaltochelatase subunit CobN.	0.544
pieE	dksA	Lery_0916	Lery_0444	Substrate of the Dot/Icm secretion system.	DnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression.	0.765
pieE	hemD	Lery_0916	Lery_1659	Substrate of the Dot/Icm secretion system.	uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.	0.434
pieE	hisI	Lery_0916	Lery_0995	Substrate of the Dot/Icm secretion system.	phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family.	0.493
pieE	map	Lery_0916	Lery_1034	Substrate of the Dot/Icm secretion system.	Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.	0.861
pieE	rpmB	Lery_0916	Lery_1318	Substrate of the Dot/Icm secretion system.	50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family.	0.723